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KMID : 0362220110380030233
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Journal of The Korean Research Society for Dental Materials
2011 Volume.38 No. 3 p.233 ~ p.238
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Fabrication of Bioactive Silica Gel-Polycaprolactone Hybrid Microparticles Capable of Drug Delivery
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Park Jong-Sup
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Abstract
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Bioactive ceramic-polymer hybrid microparticles were fabricated and examined for drug delivery capability in this study. Particulated silica gel synthesized via sol-gel method was used for ceramic component, and biodegradable polycaprolactone was used as polymer matrix. Amount of silica gel particles against matrix was fixed in 30 wt% to be well dispersed in the composite, resulting in formation of microparticles. Average size of the hybrid particles synthesized was about 385 ㎛. Bioactivity of the hybrid material was confirmed by hydroxyapatite layer formed on the surface of microparticles after soaking in simulated body fluid. Tetracycline was incorporate in the hybrid microparticles to evaluate capability of drug delivery in phosphate buffered solution. Tetracycline socked in the microparticles was released slowly about 55% up to 4 weeks. From the results, the silica gel-polycaprolactone hybrid microparticles can be used for potential
carrier for drug delivery and regeneration of bone.
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KEYWORD
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Bone regeneration, Drug delivery system, Microparticles, Polycaprolactone, Silica-gel
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